Two sample MR report
FAM110A_Interstitial Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 7 | -0.0072573 | 0.0647802 | 0.9151580 |
| Weighted median | 7 | -0.0247936 | 0.0096828 | 0.0104501 |
| Inverse variance weighted | 7 | -0.0203989 | 0.0077663 | 0.0086242 |
| Simple mode | 7 | -0.0265581 | 0.0133882 | 0.0945388 |
| Weighted mode | 7 | -0.0262615 | 0.0143674 | 0.1173361 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.589773 | 5 | 0.9024833 |
| Inverse variance weighted | 1.631527 | 6 | 0.9502841 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0077255 | 0.0378073 | 0.8461462 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001593 | 0 | TRUE | 0.2307488 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
